3-Hydroxybenzaldehyde → 3-(3-Methoxypropoxy)benzaldehyde
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[CH3:10][O:11][CH2:12][CH2:13][CH2:14]OS(C)(=O)=O>CN(C=O)C>[CH3:10][O:11][CH2:12][CH2:13][CH2:14][O:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6]参加物
4
実験手順
Alkylation of 3-hydroxybenzaldehyde (11) with methanesulfonic acid 3-methoxypropyl ester following the method used in Example 34 except that the reaction solvent was DMF gave 3-(3-methoxypropoxy)benzaldehyde as a clear oil. Yield (1.32 g, 55%): 1H NMR (400 MHz, CDCl3) δ 9.97 (s, 1H), 7.40-7.47 (m, 3H), 7.15-7.20 (m, 1H), 4.12 (t, J=6.4 Hz, 2H), 3.56 (t, J=6.2 Hz, 2H), 3.35 (s, 3H), 2.05-2.11 (m, 2H).
出典と根拠
- ORDレコード
- ord-da368732e2bc411c9ea8245a2f540f5a
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829244B2
反応ノート
読み込み中…