反応式
[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:19][CH:18]([OH:20])[CH2:17]3)[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.C(OCC)(=O)C.[ClH:27]>C(OCC)(=O)C>[ClH:27].[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:17][CH:18]([OH:20])[CH2:19]3)[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1参加物
4
実験手順
In 3.0 mL of ethyl acetate was dissolved 0.28 g of 1-{3-[2-(1-benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol, and to the solution was added 0.35 mL of a 3.25 mol/L dried hydrogen chloride-ethyl acetate solution, after which the resulting mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off under reduced pressure to obtain 0.30 g of 1-{3-[2-(1-benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol hydrochloride as a light-yellow oil.
後処理
- distillationThen, the solvent was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-8299922f87304667a70416c850fe5f40
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087594B2
関連ノート
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