化工社化工社 化学情報印刷レポート · 研究参考用
(2,6-Dimethylphenyl)methanol → 2-(2-(3-(2,6-Dimethylbenzyloxy)phenoxy)ethyl)isoindoline-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2,6-Dimethylphenyl)methanol | HCID 186748 | — |
| 反応物 | 2-[2-(3-Hydroxy-phenoxy)-ethyl]-isoindole-1,3-dione | HCID 58027534 | — |
| 生成物 | 2-(2-(3-(2,6-Dimethylbenzyloxy)phenoxy)ethyl)isoindoline-1,3-dione | HCID 67317099 | — |
反応手順
Mitsunobu reaction of phenol 24 with 2,6-dimethylbenzyl alcohol gave 2-(2-(3-(2,6-dimethylbenzyloxy)phenoxy)ethyl)isoindoline-1,3-dione as yellow oil. Yield (1.2 g, 85%): 1H NMR (400 MHz, CDCl3) δ 7.85-7.88 (m, 2H), 7.71-7.74 (m, 2H), 7.12-7.18 (m, 1H), 7.01-7.10 (m, 3H), 6.60 (dd, J=8.0, 1.8 Hz, 1H), 6.57 (s, 1H), 6.51 (dd, J=8.0, 1.8 Hz, 1H), 4.99 (s, 2H), 4.09-4.24 (m, 4H), 2.38 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829244B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-ed6dda19afe94b41a647efb79743d109 |
| 出典メモ | uspto-grants-2014_09 |