3-Phenylpropylamine → N-(3-Phenylpropyl)-3-(1H-imidazol-4-yl)propanamide
反応式
[C:1]1([CH2:7][CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:11]1[CH:15]=[C:14]([CH2:16][CH2:17][C:18](O)=[O:19])[N:13]=[CH:12]1>>[C:1]1([CH2:7][CH2:8][CH2:9][NH:10][C:18](=[O:19])[CH2:17][CH2:16][C:14]2[N:13]=[CH:12][NH:11][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
3
実験手順
The preparation is carried out as in Example 1 with 3-phenylpropanamine and 3-(1H-imidazol-4-yl)propanoic acid, the acid being here added after the reaction of the amine component with N,N'-carbonyldiimidazole. The title compound is extracted from water with diethyl ether, purified by chromatography and recrystallized in the hydrogenmaleate form from ethanol/diethyl ether.
後処理
- additionthe acid being here added
- extractionThe title compound is extracted from water with diethyl ether
- custompurified by chromatography
- customrecrystallized in the hydrogenmaleate form from ethanol/diethyl ether
出典と根拠
- ORDレコード
- ord-424f81e7bb5f47f0b2ca280258f28261
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05559113
反応ノート
読み込み中…