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Styrene Oxide → 2-(3-(3-(2-Hydroxy-2-phenylethoxy)phenyl)propyl)isoindoline-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Styrene Oxide | HCID 7276 | — |
| 反応物 | 2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione | HCID 58027542 | — |
| 生成物 | 2-(3-(3-(2-Hydroxy-2-phenylethoxy)phenyl)propyl)isoindoline-1,3-dione | HCID 67317841 | — |
反応手順
Alkylation reaction of phenol 58 with styrene oxide gave 2-(3-(3-(2-hydroxy-2-phenylethoxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.78 g, 58%): 1H NMR (400 MHz, CDCl3) δ 7.50-7.54 (m, 2H), 7.42-7.47 (m, 2H), 7.31-7.41 (m, 5H), 7.16-7.20 (m, 1H), 6.80-6.84 (m, 2H), 6.71 (dd, J=8.4, 2.2 Hz, 1H), 5.10 (dd, J=8.4, 3.2 Hz, 1H), 4.08 (d, J=6.4 Hz, 2H), 3.44-3.49 (m, 2H), 2.68 (t, J=7.4 Hz, 2H), 1.90-1.98 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829244B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-9e24fcfa97974864a4ca3c6b3476714e |
| 出典メモ | uspto-grants-2014_09 |