1,3-Benzenediol, 4-methyl- → 5-(Cyclohexylmethoxy)-2-methylphenol

HRID 74413

反応式

HRID 74413 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[OH:9].Br[CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH:12]1([CH2:11][O:8][C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([OH:9])[CH:4]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

参加物

3

反応物 2

HCID 103331,3-Benzenediol, 4-methyl-HCID 137636Cyclohexane, (bromomethyl)-

生成物 1

HCID 673166755-(Cyclohexylmethoxy)-2-methylphenol

実験手順

Alkylation of 4-methylbenzene-1,3-diol using (bromomethyl)cyclohexane following the method used in Example 154 gave 5-(cyclohexylmethoxy)-2-methylphenol as a light yellow oil. Yield (0.15 g, 8.5%): 1H NMR (400 MHz, CDCl3) δ 6.96 (d, J=8.4 Hz, 1H), 6.36-6.41 (m, 2H), 3.68 (d, J=6.4 Hz, 2H), 2.16 (s, 3H), 1.64-1.89 (m, 6H), 1.14-1.34 (m, 3H), 0.96-1.08 (m, 2H).

出典と根拠

ORDレコード
ord-9007ca62883f426fa61a1eaa9a09d29c
出典データセット
uspto-grants-2014_09
特許番号
US08829244B2

関連ノート

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