[(2S,3S,4S,5S)-3,4-dibenzoyloxy-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl benzoate → 1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
反応式
C([O:9][C@H:10]1[C@@H:14]([O:15]C(=O)C2C=CC=CC=2)[C@H:13]([CH2:24][O:25]C(=O)C2C=CC=CC=2)[O:12][C@@H:11]1[N:34]1[CH:41]=[C:40]([F:42])[C:38](=[O:39])[NH:37][C:35]1=[O:36])(=O)C1C=CC=CC=1>N.CO>[C@H:11]1([N:34]2[CH:41]=[C:40]([F:42])[C:38](=[O:39])[NH:37][C:35]2=[O:36])[O:12][C@@H:13]([CH2:24][OH:25])[C@H:14]([OH:15])[C@@H:10]1[OH:9]参加物
3
実験手順
Compound 5 (0.75 g, 1.30 mmol) in NH3 /MeOH (100 ml) was stirred at room temperature overnight and worked up as in Example 1, Step C to give pure 6 (0.33 g, 96%) as white crystals: m.p. 147°-148° C.
出典と根拠
- ORDレコード
- ord-bb5f3bc728284f208363b3a00dfa973a
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05559101
反応ノート
読み込み中…