Decyl chloroformate → Phthalimide hydrochloride

HRID 744423

反応式

HRID 744423 の反応式
[Cl:1]C(OCCCCCCCCCC)=O.FC1C=C2C(C(N3CCN(CC[N:33]4[C:37](=[O:38])[C:36]5=[CH:39][CH:40]=[CH:41][CH:42]=[C:35]5[C:34]4=[O:43])CC3)=NN2)=CC=1>CCOCC>[ClH:1].[C:37]1(=[O:38])[NH:33][C:34](=[O:43])[C:35]2=[CH:42][CH:41]=[CH:40][CH:39]=[C:36]12

参加物

4

反応物 2

HCID 108727Decyl chloroformateHCID 18467209N-[2-[4-(6-fluoro1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide

生成物 1

HCID 22266261Phthalimide hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of decanyl chloroformate (2.4 g, 11 mmol), and N-[2-[4-(6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide (3.9 g, 10 mmol) was warmed on the steam bath for 15 minutes. The reaction was allowed to cool to ambient temperature, and then ether was added to the residue. The resulting solid was filtered to afford N-2-[4-(1-decanoxy-6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide hydrochloride.

後処理

  1. temperaturewas warmed on the steam bath for 15 minutes
  2. filtrationThe resulting solid was filtered

出典と根拠

ORDレコード
ord-77699d4f57424e13828638df86460020
出典データセット
uspto-grants-1996_09
特許番号
US05559117

関連ノート

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