反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][C@@H:17]([OH:20])[CH2:16]2)=[CH:2]1.C(OCC)(=O)C.[ClH:27]>C(OCC)(=O)C>[ClH:27].[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][C@@H:17]([OH:20])[CH2:16]2)=[CH:2]1参加物
4
実験手順
In 5.0 mL of ethyl acetate was dissolved 0.99 g of (3R)-1-{2-[2-(1-benzothiophen-3-yl)ethoxy]ethyl}-3-pyrrolidinol, and to the solution was added 1.10 mL of a 3.25 mol/L dried hydrogen chloride-ethyl acetate solution, after which the resulting mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off under reduced pressure to obtain 1.05 g of (3R)-1-{2-[2-(1-benzothiophen-3-yl)ethoxy]ethyl}-3-pyrrolidinol hydrochloride as a light-yellow oil.
後処理
- distillationThen, the solvent was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-d365d14f8cc54d7b9e28fcf831f9508d
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087594B2
関連ノート
読み込み中…