関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Naphthalenamine, hydrochloride (1:1) | HCID 11094 | — |
| 反応物 | N-(m-ethylphenyl)-N-ethylcyanamide | HCID 10442201 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178436371 | HCID 178436371 | 67.2% |
反応手順
A mixture of N-(m-ethylphenyl)-N-ethylcyanamide (500 mg, 2.86 mmol) and 1-aminonaphthalene hydrochloride (520 mg, 2.86 mmol) was heated in a pre-heated oil bath at 160° C. for 2 hours and then allowed to cool to room temperature. The resulting solid was taken in dichloromethane and washed with 10% NaOH solution. The organic layer was concentrated and the resulting residue was flash chromatographed on silica gel to give N-(1-naphthyl)-N'-(m-ethylphenyl)-N'-ethylguanidine (610 mg, 67%) as a light brown liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05559154 |
|---|
| 出典データセット | uspto-grants-1996_09 |
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| ORD ID | ord-013ea19f33544a24a4780dd403c9b93d |
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| 出典メモ | uspto-grants-1996_09 |
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