Potassium Carbonate → 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol

HRID 744838

反応式

HRID 744838 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH2:5][OH:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][CH2:20][CH2:21][O:22][CH3:23].C(OCC)(=O)C.CCCCCC>CC(C)=O>[CH3:11][O:10][C:9]1[CH:8]=[CH:7][C:4]([CH2:5][OH:6])=[CH:3][C:2]=1[O:1][CH2:19][CH2:20][CH2:21][O:22][CH3:23]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 780893-Hydroxy-4-methoxybenzyl alcoholHCID 5245511-Bromo-3-methoxypropaneHCID 21226206Ethyl acetate hexane

生成物 1

HCID 451081634-Methoxy-3-(3-methoxypropoxy)benzenemethanol

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

7.7 g of 3-hydroxy-4-methoxy-benzyl alcohol, 10.35 g of potassium carbonate and 12.1 g of 1-bromo-3-methoxy-propane are stirred under reflux in 150 ml of acetone for 3 days. After evaporation of the solvent, water is added to the residue and extraction is carried out with ethyl acetate. After evaporation of the solvent the title compound is obtained from the organic extracts by means of FC (240 g of silica gel, dichloromethane/methanol=96:4): Rf (ethyl acetate/hexane=2:1)=0.31.

後処理

  1. customAfter evaporation of the solvent, water
  2. additionis added to the residue and extraction
  3. customAfter evaporation of the solvent the title compound
  4. customis obtained from the organic extracts by means of FC (240 g of silica gel, dichloromethane/methanol=96:4)

出典と根拠

ORDレコード
ord-90987c5053f4457cbdcb4e6353323a94
出典データセット
uspto-grants-1996_09
特許番号
US05559111

関連ノート

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