化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 3-(((Benzyloxy)carbonyl)amino)-2-methylpropanoic acid | HCID 304274 | — |
| 触媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester | HCID 22364470 | — |
反応手順
22.6 g of 3-benzyloxycarbonylamino-2(R,S)-methylpropionic acid are left to stand for 24 hours in 230 ml of methanol with a few drops of concentrated sulfuric acid. The reaction mixture is concentrated by evaporation and the residue is purified by FC (220 g of silica gel, dichloromethane). The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.60.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05559111 |
| 出典データセット | uspto-grants-1996_09 |
| ORD ID | ord-cc8983031c1e457db04f9006e1139e60 |
| 出典メモ | uspto-grants-1996_09 |