4-Nitrobenzoyl chloride → 1-(4-Nitrobenzoyl)-1,2,3,4-tetrahydroquinoline

HRID 745044ノート

反応式

HRID 745044 の反応式
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[N+:17]([C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1)([O-:19])=[O:18]>CC(C)=O.O>[N+:17]([C:20]1[CH:21]=[CH:22][C:23]([C:24]([N:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][CH2:2]2)=[O:25])=[CH:27][CH:28]=1)([O-:19])=[O:18]

参加物

6

反応物 3

HCID 85024-Nitrobenzoyl chlorideHCID 11430Potassium CarbonateHCID 694601,2,3,4-Tetrahydroquinoline

生成物 1

HCID 37636931-(4-Nitrobenzoyl)-1,2,3,4-tetrahydroquinoline収率 67.1%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒2 回

実験手順

To a solution of 1,2,3,4-tetrahydroquinoline (28.7 g) in acetone (400 ml) and water (200 ml) is added potassium carbonate (38.8 g), and thereto is added p-nitrobenzoyl chloride (40 g) under ice-cooling and the mixture is stirred at room temperature overnight. To the reaction mixture is added a suitable amount of water. The precipitated crystal is collected by filtration and dried to give 1-(4-nitrobenzoyl)-1,2,3,4-tetrahydroquinoline (40.8 g) as white powder, m.p. 86°-88° C.

後処理

  1. temperaturecooling
  2. filtrationThe precipitated crystal is collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-63d41ead927446428359ba9f90e1f857
出典データセット
uspto-grants-1996_09
特許番号
US05559230

反応ノート

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