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Diisopropylethylamine → (6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Octahydro-1H-indole | HCID 107275 | — |
| 反応物 | 6-Chloropyrimidine-4-carbonyl chloride | HCID 18422098 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone | HCID 58386728 | — |
反応手順
0.517 g (2.92 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 10 mL dichloromethane were combined with 1.07 mL (6.00 mmol) DIPEA. 0.73 g (2.92 mmol) octahydroindole in 10 mL DCM was slowly added dropwise. After 2 h stirring at RT the mixture was diluted with dichloromethane and extracted with water. The organic phase was separated off, dried on sodium sulphate, filtered, evaporated down i. vac. and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829006B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-d9e6d1a79cb5434b9b413788f1e27a35 |
| 出典メモ | uspto-grants-2014_09 |