Acetic Anhydride → 1-Acetyl-5-fluoro-1,3-dihydro-indol-2-one

HRID 74513ノート

反応式

HRID 74513 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)[CH2:5][C:6]1=[O:11])(=[O:14])[CH3:13]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 583867501-Acetyl-5-fluoro-1,3-dihydro-indol-2-one

実験手順

At 170° C. 3.0 g (20 mmol) 5-fluoroindolinone were stirred for 3 h in 10 mL (98 mmol) acetic anhydride. After cooling to RT the mixture was poured onto 200 mL ice water, the precipitated substance was suction filtered and washed with 100 mL water. The solid was recrystallised from 100 mL water and 50 mL ethanol at boiling temperature. The precipitated product was suction filtered, washed with 30 mL water and dried in the CAD.

後処理

  1. customAt 170° C
  2. filtrationfiltered
  3. washwashed with 100 mL water
  4. customThe solid was recrystallised from 100 mL water and 50 mL ethanol
  5. filtrationfiltered
  6. washwashed with 30 mL water
  7. customdried in the CAD

出典と根拠

ORDレコード
ord-5e3192e3dfd249f69143016f8f40d71d
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

読み込み中…