化工社化工社 化学情報印刷レポート · 研究参考用
Phenethylamine → N-[2-(Phenylsulfonyl)ethyl]benzeneethanamine, hydrochloride hemihydrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenethylamine | HCID 1001 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | ((2-Chloroethyl)sulphonyl)benzene | HCID 13646 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-[2-(Phenylsulfonyl)ethyl]benzeneethanamine, hydrochloride hemihydrate | HCID 131714769 | 89.1% |
反応手順
A mixture of 70.23 g (0.344 mole) of 2-chloroethylphenylsulfone, 41.92 g (0.343 mole) of phenethylamine and 60 ml of triethylamine in 800 ml of acetonitrile was stirred at room temperature for 18 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol and excess to ethereal hydrogen chloride was added and ether was added. A white solid precipitated to give 68.39 g (60%) of white crystalline solid, m.p. 194°-196° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04597902 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-ee976a2410fd422094e3c1c5f08f6515 |
| 出典メモ | uspto-grants-1986_07 |