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1H-Indole-3-propanoic acid → 3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-Indole-3-propanoic acid | HCID 3744 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one | HCID 4806783 | — |
反応手順
681 mg (3.60 mmol) 3-(1H-indol-3-yl)-propionic acid, 0.3 mL (3.60 mmol) pyrrolidine, 1.13 g (3.50 mmol) TBTU and 0.98 mL (7.00 mmol) triethylamine in 5.0 mL DMF were stirred overnight at RT. The mixture was purified by preparative HPLC. The product fractions were combined and evaporated down i. vac.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829006B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-1df2c89023ab44e3bf397e899e470f39 |
| 出典メモ | uspto-grants-2014_09 |