Hydrochloric Acid → N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride

HRID 745213ノート

反応式

HRID 745213 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:15](=[O:16])[CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]2[C:7]1=[O:8].[N:17]1[CH:22]=[CH:21][CH:20]=[N:19][C:18]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(=O)([O-])[O-].[K+].[K+].[ClH:35]>CN(C)C=O>[ClH:35].[N:17]1[CH:22]=[CH:21][CH:20]=[N:19][C:18]=1[N:23]1[CH2:28][CH2:27][N:26]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:15](=[O:16])[CH:10]3[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]3[C:7]2=[O:8])[CH2:25][CH2:24]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 887471-(2-Pyrimidinyl)piperazineHCID 13671565N-(4-bromobutyl)cyclohexane-1,2-dicarboximide

生成物 1

HCID 23315240N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of N-(4-bromobutyl)cyclohexane-1,2-dicarboximide (10.00 g), 1-(2-pyrimidyl)piperazine (4.75 g), anhydrous potassium carbonate powder (8.00 g) and anhydrous dimethylformamide (100 ml) was stirred at 100°-110° C. for 9 hours. The solvent was removed from the reaction mixture under reduced pressure, and the residue was purified by chromatography to give an oily substance, which was then treated with hydrogen chloride to give N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride. M.P., 168°-169° C.

後処理

  1. customThe solvent was removed from the reaction mixture under reduced pressure
  2. customthe residue was purified by chromatography
  3. customto give an oily substance, which

出典と根拠

ORDレコード
ord-6b35f752576b44fe9eb2069991caa63c
出典データセット
uspto-grants-1986_07
特許番号
US04598078

反応ノート

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