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Chloroform → 5-Hydroxy-4,5-bis-(4-methoxyphenyl)-2-thioxo-3-pyrroline-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 4,4'-Dimethoxybenzil | HCID 71043 | — |
| 反応物 | 2-Cyanoethanethioamide | HCID 1416277 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Hydroxy-4,5-bis-(4-methoxyphenyl)-2-thioxo-3-pyrroline-3-carbonitrile | HCID 13236226 | — |
反応手順
16.5 g. 4,4'-Dimethoxybenzil, 6.0 g. cyanothioacetamide and 15 drops of piperidine were boiled for 2 hours in 200 ml. chloroform on a water separator. The yellow precipitate obtained was filtered off with suction, washed with some chloroform and dried at 80° C. and 0.1 mm.Hg for 12 hours. The desired product is obtained in a yield of 17.6 g. in the form of yellow crystals; m.p. 193° C. (decomp.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04598076 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-5d8aedaf79514e46ad9aa677b0d80ce6 |
| 出典メモ | uspto-grants-1986_07 |