Benzylamine → Benzyl-(2,2,2-trifluoro-ethyl)-amine

HRID 74527

反応式

HRID 74527 の反応式
[F:1][C:2]([F:13])([F:12])[CH2:3]OS(C(F)(F)F)(=O)=O.[CH2:14]([NH2:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C(C)=CC=CC=1>[CH2:14]([NH:21][CH2:3][C:2]([F:13])([F:12])[F:1])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

生成物 1

HCID 4962181Benzyl-(2,2,2-trifluoro-ethyl)-amine

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

2.17 g (9.4 mmol) 2,2,2-trifluoroethyltrifluoromethanesulphonate were added to 2.00 g (18.7 mmol) benzylamine in 50 mL xylene and the reaction mixture was refluxed overnight. After cooling the reaction mixture was suction filtered, washed with DIPE and the filtrate was evaporated down using the rotary evaporator. The residue was purified by flash chromatography. The product fractions were combined and evaporated down using the rotary evaporator.

後処理

  1. temperaturethe reaction mixture was refluxed overnight
  2. temperatureAfter cooling the reaction mixture
  3. filtrationfiltered
  4. washwashed with DIPE
  5. customthe filtrate was evaporated down
  6. customthe rotary evaporator
  7. customThe residue was purified by flash chromatography
  8. customevaporated
  9. customthe rotary evaporator

出典と根拠

ORDレコード
ord-12297a9fd6ac4c479c6a214c31118f3c
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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