Triethylamine → HCID 58386575、化合物

HRID 74530ノート

反応式

HRID 74530 の反応式
CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[O:23]=[C:24]1[NH:32][C:27]2=[N:28][CH:29]=[CH:30][CH:31]=[C:26]2[N:25]1[CH:33]1[CH2:38][CH2:37][N:36]([C:39]2[N:44]=[CH:43][N:42]=[C:41]([C:45]([OH:47])=O)[CH:40]=2)[CH2:35][CH2:34]1.[N+:48]([C:51]1[CH:52]=[C:53]2[C:57](=[CH:58][CH:59]=1)[NH:56][CH2:55][CH2:54]2)([O-:50])=[O:49].C(N(CC)CC)C>CN(C=O)C.O>[N+:48]([C:51]1[CH:52]=[C:53]2[C:57](=[CH:58][CH:59]=1)[N:56]([C:45]([C:41]1[N:42]=[CH:43][N:44]=[C:39]([N:36]3[CH2:37][CH2:38][CH:33]([N:25]4[C:26]5[C:27](=[N:28][CH:29]=[CH:30][CH:31]=5)[NH:32][C:24]4=[O:23])[CH2:34][CH2:35]3)[CH:40]=1)=[O:47])[CH2:55][CH2:54]2)([O-:50])=[O:49]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 362195-NitroindolineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 583866966-[4-(2-Oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]pyrimidine-4-carboxylic acid

生成物 1

HCID 58386575HCID 58386575、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

150 mg (0.47 mmol) TBTU were added to 150 mg (0.44 mmol) 6-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid, 75 mg (0.46 mmol) 5-nitro-2,3-dihydro-1H-indole, 100 μL and (0.712 mmol) triethylamine in 1.5 mL DMF and the mixture was stirred overnight at RT. The reaction mixture was poured onto 30 mL water. The precipitated product was suction filtered and dried at 50° C. in the CAD.

後処理

  1. filtrationfiltered
  2. customdried at 50° C. in the CAD

出典と根拠

ORDレコード
ord-82f55e6c994141e0a18f1092baf0e473
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

読み込み中…