(S)-3-amino-2-oxohexahydro-1H-azepine-1-acetic acid, phenylmethyl ester → (S)-hexahydro-3-[[ethoxy(4-phenylbutyl)phosphinyl]amino]-2-oxo-1H-azepine-1-acetic acid, phenylmethyl ester

反応式

[CH2:1]([O:3][P:4](Cl)([CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:5])[CH3:2].[NH2:17][C@H:18]1[CH2:24][CH2:23][CH2:22][CH2:21][N:20]([CH2:25][C:26]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])[C:19]1=[O:36]>>[CH2:1]([O:3][P:4]([NH:17][C@H:18]1[CH2:24][CH2:23][CH2:22][CH2:21][N:20]([CH2:25][C:26]([O:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[O:27])[C:19]1=[O:36])([CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:5])[CH3:2]

参加物

反応物 2

HCID 10660087(S)-3-amino-2-oxohexahydro-1H-azepine-1-acetic acid, phenylmethyl ester

HCID 15591238Ethoxy(4-phenylbutyl)phosphinyl chloride

生成物 1

HCID 86740221(S)-hexahydro-3-[[ethoxy(4-phenylbutyl)phosphinyl]amino]-2-oxo-1H-azepine-1-acetic acid, phenylmethyl ester

実験手順

Ethoxy(4-phenylbutyl)phosphinyl chloride is reacted with (S)-3-amino-2-oxohexahydro-1H-azepine-1-acetic acid, phenylmethyl ester according to the procedure of Example 2(e) to give (S)-hexahydro-3-[[ethoxy(4-phenylbutyl)phosphinyl]amino]-2-oxo-1H-azepine-1-acetic acid, phenylmethyl ester.

出典と根拠

ORDレコード: ord-869de3f37f7b4d0b944c9abe22d2ec29
出典データセット: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04598071

反応ノート

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