Acetic Anhydride → HCID 58386747、化合物
反応式
[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:12])[NH:6]2.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([N:6]1[C:7]2[C:3](=[C:2]([F:1])[C:10]([F:11])=[CH:9][CH:8]=2)[CH2:4][C:5]1=[O:12])(=[O:15])[CH3:14]参加物
3
実験手順
2.00 g (11.8 mmol) 4,5-difluoro-1,3-dihydro-indol-2-one I were stirred in 6.62 mL (55.0 mmol) acetic anhydride for 2 h at 150° C. The reaction mixture was added to ice water, the precipitated solid was suction filtered and washed with water. The product was recrystallised from a mixture of water and ethanol, suction filtered and dried.
後処理
- filtrationfiltered
- washwashed with water
- customThe product was recrystallised from a mixture of water and ethanol, suction
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-b6935c47a9e94185b05b01ab8db6d25c
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829006B2
反応ノート
読み込み中…