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Sodium Hydroxide → 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 1-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene | HCID 13251817 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine | HCID 13251981 | 93.6% |
反応手順
533 g of 3-(4-tert.butylphenyl)-2-methylpropyl chloride and 714 g of 4-methylpiperazine were stirred for 7 hours at 140° C. and then cooled to +10° C. in an ice bath, and 400 ml of 50% strength sodium hyroxide solution were added slowly, followed by the addition of 500 ml of ether. The organic phase was separated off, dried over sodium hydroxide and distilled to give 640 g of 1-methyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazine of boiling point 135°-140° C./0.3 mbar.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04599335 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-8bdee9547f6c4f59aa42d2195697c970 |
| 出典メモ | uspto-grants-1986_07 |