Ethanol → 3-(2,6-Dimethylphenyl)propan-1-amine

HRID 745492

反応式

HRID 745492 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[CH2:9][CH2:10][CH2:11][N:12]1C(=O)C2C(=CC=CC=2)C1=O.C(O)C.NN>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[CH2:9][CH2:10][CH2:11][NH2:12]

参加物

4

反応物 3

HCID 702EthanolHCID 9321HydrazineHCID 136567382-[3-(2,6-dimethylphenyl)propyl]-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 201519293-(2,6-Dimethylphenyl)propan-1-amine収率 59%

実験手順

A 10 g (34.4 mmole) sample of the title compound of Example 33 was refluxed for 2 hours in 150 ml of ethanol containing 1.2 g (36.7 mmole) of 97% hydrazine. After concentrating the solution, the white crystalline residue was mixed with 100 ml of 10% NaOH and 100 ml of ether. The aqueous phase was separated and extracted with another 100 ml portion of ether. The combined ether extracts were than washed with water, dried over MgSO4 and stripped of all solvent under reduced pressure to yield 3.3 g (59%) of the product as an oil. This material was used without further purification.

後処理

  1. concentrationAfter concentrating the solution
  2. additionthe white crystalline residue was mixed with 100 ml of 10% NaOH and 100 ml of ether
  3. customThe aqueous phase was separated
  4. extractionextracted with another 100 ml portion of ether
  5. washthan washed with water
  6. dry with materialdried over MgSO4

出典と根拠

ORDレコード
ord-8c6d15244ef241f4a4b1f694d4b10335
出典データセット
uspto-grants-1986_07
特許番号
US04599325

関連ノート

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