化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 3-(2-Amino-2-methylpropylthio)-6-chloropyridazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3,6-Dichloropyridazine | HCID 67331 | — |
| 反応物 | 2-Amino-2-methylpropane-1-thiol | HCID 521040 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 3-(2-Amino-2-methylpropylthio)-6-chloropyridazine | HCID 10465952 | 36.4% |
反応手順
To a suspension of 1.32 g of 61% sodium hydride in 20 ml of benzene was added dropwise at room tmperature a solution of 2.6 g of 2-methyl-2-aminopropanethiol in 10 ml of benzene. Then, a solution of 4.1 g of 3,6-dichloropyridazine in 10 ml of benzene was added, and the mixture was refluxed for 6 hours. After cooling, the reaction mixture was washed with water and dried over magnesium sulfate. The solvent was evaporated to give 1.96 g of 3-(2-amino-2-methylpropylthio)-6-chloropyridazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04599333 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-d11e9d34c4b14cf696bdabc57d562ff8 |
| 出典メモ | uspto-grants-1986_07 |