o-CRESYL GLYCIDYL ETHER → 1-(2-Methylphenoxy)-3-[1,1-dimethyl-3-(chloro-6-pyridazinyloxy)propylamino]-2-propanol
反応式
[NH2:1][C:2]([CH3:14])([CH3:13])[CH2:3][CH2:4][O:5][C:6]1[N:7]=[N:8][C:9]([Cl:12])=[CH:10][CH:11]=1.[CH3:15][C:16]1[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=1[O:18][CH2:19][CH:20]1[O:22][CH2:21]1>CO>[CH3:15][C:16]1[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=1[O:18][CH2:19][CH:20]([OH:22])[CH2:21][NH:1][C:2]([CH3:14])([CH3:13])[CH2:3][CH2:4][O:5][C:6]1[N:7]=[N:8][C:9]([Cl:12])=[CH:10][CH:11]=1参加物
4
実験手順
A mixture of 645 mg of 3-(3-amino-3-methylbutoxy)-6-chloropyridazine, 650 mg of 1-(2-methylphenoxy)-2,3-epoxypropane and 15 ml of methanol was refluxed for 5 hours, and the solvent was evaporated under reduced pressure. A solution of the residue in benzene was extracted with 1N hydrochloric acid. The aqueous layer was extracted with chloroform, and the organic layer was washed with 5% sodium carbonate, and dried over anhydrous sodium sulfate. The solvent was evaporated to give 938 mg of 1-(2-methylphenoxy)-3-[1,1-dimethyl-3-(chloro-6-pyridazinyloxy)propylamino]-2-propanol as an oil.