O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 58386435、化合物

HRID 74554

反応式

HRID 74554 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]4[N:25]=[CH:24][N:23]=[C:22]([C:26]([O:28]C(C)(C)C)=[O:27])[C:21]=4[CH3:33])[CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:34]=1.FC1C=C2C(=CC=1)NCC2.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:15][CH2:16][N:17]([C:20]4[N:25]=[CH:24][N:23]=[C:22]([C:26]([OH:28])=[O:27])[C:21]=4[CH3:33])[CH2:18][CH2:19]3)[CH2:9][CH2:8][C:7]=2[CH:34]=1

参加物

5

反応物 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27744635-FluoroindolineHCID 58386534Tert. butyl 6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-5-methyl-pyrimidin-4-carboxylate

生成物 1

HCID 58386435HCID 58386435、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

70 mg (0.17 mmol) tert. butyl 6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-5-methyl-pyrimidin-4-carboxylate, 26 mg (0.19 mmol) 5-fluoroindoline, 61 mg (0.19 mmol) TBTU and 27 μL (0.19 mmol) TEA were stirred in 1.0 mL DMF for 3 h at RT. The reaction mixture was purified by HPLC. The product-containing fractions were combined and freeze-dried.

後処理

  1. customThe reaction mixture was purified by HPLC
  2. customfreeze-dried

出典と根拠

ORDレコード
ord-a503c57dd4264e0c8f32ab98bd540b0c
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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