Ammonia → HCID 58386658、化合物

HRID 74555

反応式

HRID 74555 の反応式
Br[C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][CH:14]([N:17]2[C:25]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:19][C:18]2=[O:26])[CH2:13][CH2:12]1.N>O>[O:26]=[C:18]1[NH:19][C:20]2=[N:21][CH:22]=[CH:23][CH:24]=[C:25]2[N:17]1[CH:14]1[CH2:15][CH2:16][N:11]([C:2]2[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=2)[CH2:12][CH2:13]1

参加物

5

反応物 3

HCID 222AmmoniaHCID 2227012-Bromoisonicotinic acidHCID 22293182Bms-973013

生成物 1

HCID 58386658HCID 58386658、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.50 g (2.4 mmol) 2-bromopyridine-4-carboxylic acid and 1.1 g (5.0 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one were mixed and melted for 10 min using the hot air blower. The reaction mixture was cooled, mixed with water and made basic with ammonia. It was extracted with EtOAc. The aqueous phase was concentrated and purified by HPLC. The product-containing fractions were combined and concentrated to dryness by rotary evaporation.

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionIt was extracted with EtOAc
  3. concentrationThe aqueous phase was concentrated
  4. custompurified by HPLC
  5. concentrationconcentrated to dryness by rotary evaporation

出典と根拠

ORDレコード
ord-d9b8229d44f84c40bdf10d0071e87ef6
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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