1-(4-Chlorophenyl)-2-[(3-oxo-1-azabicyclo[2.2.2]oct-2-yl)methyl]-1,3-butanedione hydrochloride → 2-[3-(4-Chlorophenyl)-3-oxopropyl]-1-azabicyclo[2.2.2]octan-3-one hydrochloride
反応式
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:24])[CH:10]([CH2:14][CH:15]2[C:20](=[O:21])[CH:19]3[CH2:22][CH2:23][N:16]2[CH2:17][CH2:18]3)C(=O)C)=[CH:5][CH:4]=1>Cl>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([C:9](=[O:24])[CH2:10][CH2:14][CH:15]2[C:20](=[O:21])[CH:19]3[CH2:22][CH2:23][N:16]2[CH2:17][CH2:18]3)=[CH:7][CH:8]=1参加物
3
実験手順
Reflux 105.28 g (0.28 mole) 1-(4-chlorophenyl)-2-[(3-oxo-1-azabicyclo[2.2.2]oct-2-yl)methyl]-1,3-butanedione hydrochloride in 500 ml concentrated hydrochloric acid for 5 hours. Stir with mechanical stirrer. Chill the reaction mixture in an ice bath and collect the title compound via filtration.
後処理
- temperatureChill the reaction mixture in an ice bath