Methyl Isocyanate → HCID 23313764、化合物
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:9](=[O:21])[CH2:10][CH2:11][CH:12]2[C:17](=[O:18])[CH:16]3[CH2:19][CH2:20][N:13]2[CH2:14][CH2:15]3)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:22][N:23]=[C:24]=[O:25]>C(Cl)Cl>[ClH:8].[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([C:9](=[O:21])[CH2:10][CH2:11][CH:12]2[C:17](=[O:18])[CH:16]3[CH2:19][CH2:20][N:13]2[CH2:14][CH2:15]3)=[CH:3][C:2]=1[NH:1][C:24]([NH:23][CH3:22])=[O:25]参加物
4
実験手順
To 6.14 g (0.02 mole) of 2-[3-(3-amino-4-chlorophenyl)-3-oxopropyl]-1-azabicyclo[2.2.2]octan-3-one in 150 ml of methylene chloride add 1.20 g (0.021 mole) of methyl isocyanate. Stir the reaction mixture at room temperature and follow the progress of the reaction by thin-layer chromatography. At the completion of the reaction remove the solvent in vacuo. Dissolve the residue in 100 ml of ethanol and add 2.5 ml of concentrated hydrochloric acid. Remove the solvent in vacuo to obtain the title compound.