Ammonia → HCID 2755910、化合物
反応式
Cl.[CH3:2][C:3]1([CH3:17])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]1[C:12](OCC)=[O:13].[NH3:18]>C(O)C>[CH3:2][C:3]1([CH3:17])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]1[C:12]([NH2:18])=[O:13]参加物
4
実験手順
The solution of 1 g of ethyl 3,3-dimethylindoline-2-carboxylate hydrochloride in 25 ml of ethanol is saturated with anhydrous ammonia and heated in a closed vessel to 50° for 4 days. It is evaporated, the residue crystallized from diethyl ether, suspended in water and 3N aqueous sodium hydroxide is added to render the mixture basic. It is extracted with methylene chloride, the extract dried and evaporated, to yield the 3,3-dimethylindoline-2-carboxamide melting at 156°-158°.
後処理
- temperatureheated in a closed vessel to 50° for 4 days
- customIt is evaporated
- customthe residue crystallized from diethyl ether
- addition3N aqueous sodium hydroxide is added to render the mixture basic
- extractionIt is extracted with methylene chloride
- customthe extract dried
- customevaporated
出典と根拠
- ORDレコード
- ord-1da7de8daefb403ca813120d7debada6
- 出典データセット
- uspto-grants-1986_07
- 特許番号
- US04599357
反応ノート
読み込み中…