Stearoyl chloride → HCID 70359046、化合物

HRID 745715ノート

反応式

HRID 745715 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH:6]([OH:15])[C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(Cl)(=O)CCCCCCCCCCCCCCCCC.C1(C(C(C2C=CC=CC=2)O)=O)C=CC=CC=1.C(S([O-])(=O)=O)CCCCCCCCCCCCCCC.F[C:76](F)([C:80](F)(F)[C:81](F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)[C:77]([O-:79])=[O:78]>C(N(CC)CC)C.C1(C)C=CC=CC=1>[C:77]([OH:79])(=[O:78])[CH2:76][CH2:80][CH2:81][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:8][CH2:7][CH2:6][CH2:5][CH2:16][CH2:17][CH2:18][CH2:3][CH3:4].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH:6]([OH:15])[C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

8

反応物 5

HCID 8212Stearoyl chlorideHCID 8400BenzoinHCID 4622696HCID 4622696、化合物2 回HCID 4986139Perfluorooctanoate2 回HCID 9991962HCID 9991962、化合物

生成物 1

HCID 70359046HCID 70359046、化合物

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒2 回HCID 8471Triethylamine溶媒

実験手順

3'-Methoxybenzoin (5 g, 0.021 mol) was dissolved in 200 ml of toluene containing one equivalent of triethylamine. One equivalent of octadecanoyl chloride in 20 ml of toluene was added slowly to the cooled (ice bath) stirred benzoin solution. Stirring was continued with ice bath cooling for one hour. The reaction mixture was then filtered free of precipitated amine salt and the filtrate was evaporated to give an oil which solidified to give a low melting solid. The hexadecanesulfonate (Compound 14) and perfluorooctanoate (Compound 15) (m.p. 55°-58° C.) esters were similarly prepared from the corresponding acid chlorides.

後処理

  1. temperaturecooled (ice bath)
  2. customwas continued with ice bath
  3. temperaturecooling for one hour
  4. filtrationThe reaction mixture was then filtered free of precipitated amine salt
  5. customthe filtrate was evaporated
  6. customto give an oil which
  7. customto give a low melting solid

出典と根拠

ORDレコード
ord-416b98a08c984043b5c0db4327ba5941
出典データセット
uspto-grants-1986_07
特許番号
US04599273

反応ノート

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