methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate → methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate

HRID 74573

反応式

HRID 74573 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][NH:8]2)([O-])=O.[H][H]>CO.[Ni]>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][NH:8]2

参加物

5

反応物 2

HCID 10243182methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 10104433methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

2.0 g (8.5 mmol) methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate in 70 mL MeOH were combined with 0.30 g Raney nickel and hydrogenated for 2 h in a hydrogen atmosphere. The catalyst was removed by suction filtering and the solution was concentrated by rotary evaporation. The residue was immediately reacted further without further purification.

後処理

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. concentrationthe solution was concentrated by rotary evaporation
  4. customThe residue was immediately reacted further without further purification

出典と根拠

ORDレコード
ord-5ff40530b07748d5b45375c1bd584cf4
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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