化工社化工社 化学情報印刷レポート · 研究参考用
methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate → 1,2,2a,5-Tetrahydropyrrolo[4,3,2-de]quinolin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate | HCID 10104433 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 1,2,2a,5-Tetrahydropyrrolo[4,3,2-de]quinolin-4(3H)-one | HCID 10442192 | — |
反応手順
1.80 g (8.73 mmol) methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate in 100 mL xylene were refluxed for 30 h. The reaction mixture was evaporated down and purified by flash chromatography. The product-containing fractions were combined and evaporated down.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829006B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-cdbb45a4f8dd41cead89feda40477465 |
| 出典メモ | uspto-grants-2014_09 |