Methanol → 2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl-
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH3:12]O>[Ni]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH:5]2[CH3:12]参加物
4
実験手順
3.0 g (20 mmol) 5-fluoro-1,3-dihydro-indol-2-one, 50 mL methanol and 2.0 g Raney nickel were stirred for 1.5 h at 200° C. in an autoclave. After the catalyst had been filtered off the mother liquor was evaporated down and the residue was recrystallised from methanol.
後処理
- filtrationAfter the catalyst had been filtered off the mother liquor
- customwas evaporated down
- customthe residue was recrystallised from methanol
出典と根拠
- ORDレコード
- ord-66f7b41e2bb846d29f2c245d616c90b3
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829006B2
反応ノート
読み込み中…