Potassium cyanate → N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]urea

HRID 745922ノート

反応式

HRID 745922 の反応式
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:4][CH:3]=1.[O-:16][C:17]#[N:18].[K+]>Cl.O>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:14][CH:15]=1)[C:17]([NH2:18])=[O:16]

参加物

5

反応物 2

HCID 11378442Potassium cyanateHCID 135692034-[2-(1H-Imidazol-1-yl)ethoxy]aniline

生成物 1

HCID 13569204N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]urea収率 82.5%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

実験手順

1-[2-(4-Aminophenoxy)ethyl]imidazole (0.6 g) was dissolved in 1N hydrochloric acid (3.0 ml) and a solution of potassium cyanate (0.3 g) in 1 ml of water was added. The mixture was allowed to stand at room temperature for 15 minutes and the resulting solid was filtered off, washed with water and crystallised from water to give 1-[2-(4-ureidophenoxy)ethyl]imidazole (0.6 g), m.p. 199°-201° C. Found: C, 58.20; H, 5.70; N, 23.06. C12H14N4O2 requires: C, 58.52; H, 5.73; N, 22.75%.

後処理

  1. filtrationthe resulting solid was filtered off
  2. washwashed with water
  3. customcrystallised from water

出典と根拠

ORDレコード
ord-acc04cf877aa4dcd9b62f88b27580a76
出典データセット
uspto-grants-1986_07
特許番号
US04602016

反応ノート

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