Methanol → (5-Bromo-4-chloropyridin-2-yl)methanol

HRID 74596ノート

反応式

HRID 74596 の反応式
FC(F)(F)C(O[C:6](=[O:11])[C:7](F)(F)F)=O.[Br:14][C:15]1[C:16]([Cl:23])=[CH:17]C(C)=[N+:19]([O-])[CH:20]=1.CO>C(Cl)Cl>[Br:14][C:15]1[C:16]([Cl:23])=[CH:17][C:7]([CH2:6][OH:11])=[N:19][CH:20]=1

参加物

5

反応物 3

HCID 887MethanolHCID 9845Trifluoroacetic anhydrideHCID 136827785-Bromo-4-chloro-2-methylpyridine 1-oxide

生成物 1

HCID 19791171(5-Bromo-4-chloropyridin-2-yl)methanol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3.0 mL trifluoroacetic anhydride were added dropwise at 10° C. to 2.6 g (12 mmol) 5-bromo-4-chloro-2-methylpyridine-1-oxide in 30 mL DCM. The reaction mixture was stirred for 5 days at RT. After the addition of MeOH the reaction mixture was evaporated down, the residue was combined with 15% potassium carbonate solution and extracted several times with EtOAC. The combined organic phases were dried on sodium sulphate and evaporated down.

後処理

  1. customwas evaporated down
  2. extractionextracted several times with EtOAC
  3. customThe combined organic phases were dried on sodium sulphate
  4. customevaporated down

出典と根拠

ORDレコード
ord-3c280e930d3a4fb9aa6a1b2618d9a15a
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

反応ノート

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