Hydrogen Peroxide → 2-[[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]sulfinyl]-2-methylpropionic acid

HRID 745988ノート

反応式

HRID 745988 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([S:17][C:18]([CH3:23])([CH3:22])[C:19]([OH:21])=[O:20])=[CH:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1.[OH:24]O>C(O)(=O)C.Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([S:17]([C:18]([CH3:23])([CH3:22])[C:19]([OH:21])=[O:20])=[O:24])=[CH:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 140125362-[[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]thio]-2-methylpropionic acid

生成物 1

HCID 136560912-[[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]sulfinyl]-2-methylpropionic acid収率 58%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 313Hydrochloric Acid溶媒

実験手順

5.56 g (16.0 mmol) of 2-[[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]thio]-2-methylpropionic acid and 6 ml of 30% H2O2 were combined in 200 ml glacial acetic acid. The mixture was stirred at room temperature and monitored by TLC for the disappearance of starting material and the appearance of product. After about four hours the reaction was stopped by diluting with excess 3N HCl. The resulting precipitate was filtered and washed several times with cold toluene to yield white crystals, 3.38 g (58%) of 2-[[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]sulfinyl]-2-methylpropionic acid, m.p. 184°-185° C.

後処理

  1. filtrationThe resulting precipitate was filtered
  2. washwashed several times with cold toluene

出典と根拠

ORDレコード
ord-64a897c576b4455899f8b587f161f1d8
出典データセット
uspto-grants-1986_07
特許番号
US04602028

反応ノート

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