Ethanol → HCID 20240708、化合物

HRID 746115ノート

反応式

HRID 746115 の反応式
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[F:17][C:18]([F:34])([F:33])[C:19]1[CH:20]=[CH:21][C:22]([O:25][C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)=[N:23][CH:24]=1.C(O)C>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:30][C:29]2[CH:31]=[CH:32][C:26]([O:25][C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:34])([F:17])[F:33])=[CH:24][N:23]=3)=[CH:27][CH:28]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

参加物

5

反応物 3

HCID 702EthanolHCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 27830854-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline

生成物 1

HCID 20240708HCID 20240708、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

1.60 g (0.007 mol) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 1.78 g (0.007 mol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline are suspended in 20 ml of toluene. The suspension is heated to reflux for 16 hours, during which time ethanol escapes. After cooling, the precipitate is isolated by filtration, washed with toluene and dried, affording 1,3-dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]barbituric acid of the formula ##STR24## with a melting point of 180°-181° C.

後処理

  1. temperatureThe suspension is heated
  2. temperatureAfter cooling
  3. customthe precipitate is isolated by filtration
  4. washwashed with toluene
  5. customdried

出典と根拠

ORDレコード
ord-ad9e6b3518fe46199102c704e4503b77
出典データセット
uspto-grants-1986_07
特許番号
US04602912

反応ノート

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