Phosphorus tribromide → 2,2,5,5-Tetramethyl-1-cyclopentylmethylbromide

HRID 746166

反応式

HRID 746166 の反応式
[CH3:1][C:2]1([CH3:11])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[CH:3]1[CH2:9]O.P(Br)(Br)[Br:13]>C1C=CC=CC=1>[CH3:1][C:2]1([CH3:11])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[CH:3]1[CH2:9][Br:13]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 13629260(2,2,5,5-Tetramethylcyclopentyl)methanol

生成物 1

HCID 136292612,2,5,5-Tetramethyl-1-cyclopentylmethylbromide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

反応条件

温度
0 °C

実験手順

2,2,5,5-Tetramethyl-1-cyclopentylmethanol is dissolved in benzene and stirred at 0° C. under argon. A solution of phosphorus tribromide in benzene is added and the mixture is stirred for 2 hours and then heated to 60° C. for 4 hours. The mixture is cooled, poured into ice and extracted with ether. The organic layer is washed with saturated NaHCO3, dried over MgSO4 and evaporated to yield 2,2,5,5-Tetramethyl-1-cyclopentylmethylbromide.

後処理

  1. stirringthe mixture is stirred for 2 hours
  2. temperatureheated to 60° C. for 4 hours
  3. temperatureThe mixture is cooled
  4. additionpoured into ice
  5. extractionextracted with ether
  6. washThe organic layer is washed with saturated NaHCO3
  7. dry with materialdried over MgSO4
  8. customevaporated

出典と根拠

ORDレコード
ord-addd536eb96b4667ab5273c8f70e4523
出典データセット
uspto-grants-1986_07
特許番号
US04603012

関連ノート

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