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Boron trifluoride etherate → N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 反応物 | 2,2,4,4-Tetramethylpentan-3-ol | HCID 139790 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Benzyl 2-methylaziridine-1-carboxylate | HCID 21895246 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane | HCID 20201216 | — |
反応手順
N-Cbz-2-Methyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and are extracted with ethyl acetate. The organic layer is drid over MgSO4 and evaporated to yield N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04603011 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-a314b7ccc7ef4bcc8f231c992f29236a |
| 出典メモ | uspto-grants-1986_07 |