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Hydrochloric Acid → Z-Lys(Boc)-Phe-Phe-OH
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethylmorpholine | HCID 7525 | — |
| 反応物 | IN2-(benzyloxycarbonyl)-N6-(tert-butoxycarbonyl)-L-lysine | HCID 98765 | — |
| 反応物 | L-Phenylalanyl-L-phenylalanine | HCID 6993090 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Z-Lys(Boc)-Phe-Phe-OH | HCID 131714787 | — |
反応手順
4.19 g of Z-Lys(Boc)-OPc and 2.47 g of HCl.H-Phe-Phe-OH are taken up in 50 ml of dimethylformamide, 0.84 ml of N-ethylmorpholine are added and the whole is left to stand for 24 hours at 20°. The reaction mixture is concentrated by evaporation and the residue is triturated with water and dried over phosphorus pentoxide. Recrystallisation from ether yields crystals having a melting point of 154° to 156°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04603120 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-58f6271e8c0d42118b25fb5f5ea2c0ab |
| 出典メモ | uspto-grants-1986_07 |