Hydrochloric Acid → Z-Lys(Boc)-Phe-Phe-OH

HRID 746201

反応式

HRID 746201 の反応式
[NH:1]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[C@H:2]([C:15]([OH:17])=O)[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].Cl.[NH2:29][C@H:30]([C:38]([NH:40][C@H:41]([C:49]([OH:51])=[O:50])[CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)=[O:39])[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.C(N1CCOCC1)C>CN(C)C=O>[NH:1]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[C@H:2]([C:15]([NH:29][C@H:30]([C:38]([NH:40][C@H:41]([C:49]([OH:51])=[O:50])[CH2:42][C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=1)=[O:39])[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:17])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7525EthylmorpholineHCID 98765IN2-(benzyloxycarbonyl)-N6-(tert-butoxycarbonyl)-L-lysineHCID 6993090L-Phenylalanyl-L-phenylalanine

生成物 1

HCID 131714787Z-Lys(Boc)-Phe-Phe-OH

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4.19 g of Z-Lys(Boc)-OPc and 2.47 g of HCl.H-Phe-Phe-OH are taken up in 50 ml of dimethylformamide, 0.84 ml of N-ethylmorpholine are added and the whole is left to stand for 24 hours at 20°. The reaction mixture is concentrated by evaporation and the residue is triturated with water and dried over phosphorus pentoxide. Recrystallisation from ether yields crystals having a melting point of 154° to 156°.

後処理

  1. waitthe whole is left
  2. concentrationThe reaction mixture is concentrated by evaporation
  3. customthe residue is triturated with water
  4. dry with materialdried over phosphorus pentoxide
  5. customRecrystallisation from ether
  6. customyields crystals

出典と根拠

ORDレコード
ord-58f6271e8c0d42118b25fb5f5ea2c0ab
出典データセット
uspto-grants-1986_07
特許番号
US04603120

関連ノート

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