1-Benzylpiperazine → 2-[(4-Benzylpiperazin-1-yl)methyl]-1H-benzimidazole

HRID 746212ノート

反応式

HRID 746212 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:15][C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:15][C:16]2[NH:17][C:18]3[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=3[N:20]=2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 759941-BenzylpiperazineHCID 785712-Chloromethylbenzimidazole

生成物 1

HCID 136569962-[(4-Benzylpiperazin-1-yl)methyl]-1H-benzimidazole収率 83.4%

実験手順

In the same manner as described in Reference Example 4, N-benzylpiperazine (20 g) and 2-chloromethylbenzimidazole (9.0 g) are reacted, and the crude crystal thus obtained is recrystallized from ethyl acetate to give 2-(4-benzyl-1-piperazinyl)methylbenzimidazole (13.8 g) as pale yellow needles, m.p. 195°-201° C.

後処理

  1. customare reacted
  2. customthe crude crystal thus obtained
  3. customis recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-d1ebb21bd3514963b1c12edc47e99675
出典データセット
uspto-grants-1986_07
特許番号
US04603130

反応ノート

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