Triethylamine → HCID 58386394、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Triethylamine	HCID 8471	—
反応物	2,3,4,5-Tetrahydro-1H-benzo(d)azepine	HCID 1400243	—
反応物	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
反応物	6-[4-(2-Oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]pyrimidine-4-carboxylic acid	HCID 58386696	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	HCID 58386394	HCID 58386394	—

反応手順

100.0 mg (0.29 mmol) 6-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid, 50.0 mg (0.34 mmol) 2,3,4,5-tetrahydro-1H-3-benzazepine, 100 μL (0.71 mmol) triethylamine and 100.0 mg (0.31 mmol) TBTU in 1.5 mL DMF were stirred overnight at RT. The reaction mixture was filtered through a syringe filter and the solution was purified by preparative HPLC. The product fractions were combined and lyophilised.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08829006B2
出典データセット	uspto-grants-2014_09
ORD ID	ord-6f9496dd18b0417d81a00c7a0f295a62
出典メモ	uspto-grants-2014_09