3-Chlorophenylboronic acid ethylene glycol ester → (3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid

HRID 746478ノート

反応式

HRID 746478 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([Mg]Br)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[B:13](OCCO)([OH:21])[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=1>>[Cl:20][C:16]1[CH:15]=[C:14]([B:13]([C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[OH:21])[CH:19]=[CH:18][CH:17]=1

参加物

3

反応物 2

HCID 692083603-Chlorophenylboronic acid ethylene glycol esterHCID 178491916HCID 178491916、化合物

生成物 1

HCID 69207503(3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid

実験手順

(3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid was prepared from 3,4-dimethoxyphenylmagnesium bromide and 3-chlorophenylboronic acid ethylene glycol ester by the procedure described in Example 6a. The title complex product was made by the methodology described in Section 5.3.7.1, and obtained as yellow crystals. MS (ESI, positive): m/z=404 (M+1); 1H NMR (DMSO-d6, 300 MHz): δ 9.17 (d, 1H), 8.78 (d, 1H), 7.90 (dd, 1H), 7.70 (t, 1H), 7.43 (d, 1H), 7.30-7.17 (m, 5H), 6.89-6.80 (m, 3H), 3,66 (s, 3H) and 3.62 (s, 3H) ppm.

後処理

  1. customobtained as yellow crystals

出典と根拠

ORDレコード
ord-44af01f9e8b24b36b3e2c4716540a207
出典データセット
uspto-grants-2008_07
特許番号
US07393856B2

反応ノート

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