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Isopropanol → 4-(3-Hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 5-Amino-2-methylphenol | HCID 17818 | — |
| 反応物 | 4-Chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 10707048 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(3-Hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 21991015 | — |
反応手順
A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.4 g, 1.5 mmol) and 3-hydroxy-4-methylaniline (0.2 g, 1.6 mmol) in DMF (5 ml) was heated at 150° C. for 20 minutes. After cooling, isopropanol (15 ml) was added and the resulting solid filtered off, washed with isopropanol and dried under vacuum to give 4-(3-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (yellow solid, 537 mg 91%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087602B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-ab4f8a23c5f44853b3e7c6c03e59182c |
| 出典メモ | uspto-grants-2006_08 |