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Methyl iodide → 4-Bromo-2,6-difluoroanisole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromo-2,6-difluorophenol | HCID 2736292 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-Bromo-2,6-difluoroanisole | HCID 2773287 | — |
反応手順
Add iodomethane (2.0 ml, 32.1 mmol) dropwise to a suspension of 4-bromo-2,6-difluorophenol (5.90 g, 28.2 mmol) and potassium carbonate (4.40 g, 31.8 mmol) in acetone (50 ml) at room temperature while stirring vigorously. Heat the mixture under reflux overnight. Evaporate acetone and add dichloromethane. Filter through silica eluting the product with dichloromethane/EtOAc. Concentrate to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07393868B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-a291ed1aa0994e328206e6d5aeacc4dc |
| 出典メモ | uspto-grants-2008_07 |