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Sodium Carbonate → Methyl 3-amino-4-bromobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Sodium Dithionite | HCID 24489 | — |
| 反応物 | Methyl 4-bromo-3-nitrobenzoate | HCID 2736829 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl 3-amino-4-bromobenzoate | HCID 3928639 | 51% |
反応手順
Dissolve 4-bromo-3-nitro-benzoic acid methyl ester (4.25 g, 16.3 mmol) in ethanol (100 ml) and water (30 ml). Add sodium dithionite (15 g, 75 mmol) in a single portion and heat the mixture under reflux for 4 h. Evaporate ethanol and add water. Basify the aqueous layer with 10% sodium carbonate solution. Extract the product with EtOAc (×2). Dry the combined organic layers over anhydrous sodium sulfate, filter and concentrate to yield 3-amino-4-bromo-benzoic acid methyl ester (51%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07393868B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-b9d219e6a7d04344a1361ae76bb5d92d |
| 出典メモ | uspto-grants-2008_07 |